Soon after the release of their record, Iryn left for France and the group disbanded. This break up would later lead to wide speculation that the two separated on unfriendly terms although they both denied such rumors. While in France, she formed the Afro-Soul group Nujeli together with Julien Grout and they released songs like Nsangi, Eko, Ensi and Baami Baffe.
But these songs were not successful in Uganda. Later on, Iryn joined forces with singer Bebe cool in the songs Simbalala and Lwaki Onzannyilako?. However, Iryn didn't achieve widespread success until 2006 when she released her
album Nkuweeki?.This marked the beginning of her fast rise to be one of the best female musicians in Uganda. Since 2006, Iryn Namubiru has released several successful songs like Y'ono, Lwaki, Bonna Obasinga " Begombeko", " Birowoozo", which have earned her several leading awards in the Ugandan music industry. In 2011, Iryn capped her most successful year ever by winning in four categories of the 2011 PAM(Pearl of Africa Music) Awards. She won in the categories of Artist of the year, Female Artist of the year, Album of the year and Best RnB single of the year.